diff --git a/drugs.json b/drugs.json index 11103a7..259837f 100644 --- a/drugs.json +++ b/drugs.json @@ -33391,40 +33391,6 @@ "summary": "Sedative-Hypnotic of the nonbenzodiazepine from the Pyrazolopyramide class. It is used mostly for short term insomnia." } }, - "sr-17018": { - "aliases": [ - "sr" - ], - "categories": [ - "tentative", - "research-chemical", - "opioid", - "depressant" - ], - "name": "sr-17018", - "pretty_name": "SR-17018", - "properties": { - "aliases": [ - "sr" - ], - "categories": [ - "tentative", - "research-chemical", - "opioid", - "depressant" - ], - "chemistry": "5,6-dichloro-3-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-1H-benzimidazol-2-one; Molecular formula: C19H18Cl3N3O; Molecular weight: 410.73 g/mol", - "pharmacology": "High-efficacy biased μ-opioid receptor agonist with unique allosteric mechanism. Selective for G-protein signaling pathway over β-arrestin 2 recruitment. Achieves bias through interactions with μ receptors outside the orthosteric agonist site. Exhibits non-competitive antagonism with naloxone and cyprodime, unlike traditional opioids.", - "summary": "SR-17018 is a research chemical and biased μ-opioid receptor agonist with a distinctive allosteric mechanism. Investigated for potential to reverse morphine tolerance and prevent withdrawal while reducing respiratory depression risk. Unlike conventional opioids, it binds outside the primary agonist site and shows non-competitive antagonist interactions. Very limited human use data exists - primarily studied in laboratory settings.", - "warning": "Experimental research compound with unknown safety profile in humans. May not respond to standard opioid antagonists (naloxone) in the typical competitive manner due to allosteric mechanism." - }, - "sources": { - "_general": [ - "Fritzwanker, S., Schulz, S., & Kliewer, A. (2021). SR-17018 Stimulates Atypical µ-Opioid Receptor Phosphorylation and Dephosphorylation. Molecules, 26(15), 4509. https://doi.org/10.3390/molecules26154509", - "Singleton, S., et al. (2024). Activation of μ receptors by SR-17018 through a distinctive mechanism. Neuropharmacology, 258, 110093. https://doi.org/10.1016/j.neuropharm.2024.110093" - ] - } - }, "sufentanil": { "categories": [ "opioid", diff --git a/package-lock.json b/package-lock.json index cafe809..aed9752 100644 --- a/package-lock.json +++ b/package-lock.json @@ -1,17 +1,19 @@ { "name": "tripsit_drug_db", - "version": "1.1.0", + "version": "1.0.2", "lockfileVersion": 3, "requires": true, "packages": { "": { "name": "tripsit_drug_db", - "version": "1.1.0", + "version": "1.0.2", "license": "ISC", + "dependencies": { + "ajv": "^8.12.0", + "ajv-formats": "^3.0.1" + }, "devDependencies": { "@types/node": "^20.11.10", - "ajv": "^8.12.0", - "ajv-formats": "^3.0.1", "ts-node": "^10.9.2", "typescript": "^5.3.3" } @@ -111,7 +113,6 @@ "version": "8.12.0", "resolved": "https://registry.npmjs.org/ajv/-/ajv-8.12.0.tgz", "integrity": "sha512-sRu1kpcO9yLtYxBKvqfTeh9KzZEwO3STyX1HT+4CaDzC6HpTGYhIhPIzj9XuKU7KYDwnaeh5hcOwjy1QuJzBPA==", - "dev": true, "dependencies": { "fast-deep-equal": "^3.1.1", "json-schema-traverse": "^1.0.0", @@ -127,7 +128,6 @@ "version": "3.0.1", "resolved": "https://registry.npmjs.org/ajv-formats/-/ajv-formats-3.0.1.tgz", "integrity": "sha512-8iUql50EUR+uUcdRQ3HDqa6EVyo3docL8g5WJ3FNcWmu62IbkGUue/pEyLBW8VGKKucTPgqeks4fIU1DA4yowQ==", - "dev": true, "dependencies": { "ajv": "^8.0.0" }, @@ -164,14 +164,12 @@ "node_modules/fast-deep-equal": { "version": "3.1.3", "resolved": "https://registry.npmjs.org/fast-deep-equal/-/fast-deep-equal-3.1.3.tgz", - "integrity": "sha512-f3qQ9oQy9j2AhBe/H9VC91wLmKBCCU/gDOnKNAYG5hswO7BLKj09Hc5HYNz9cGI++xlpDCIgDaitVs03ATR84Q==", - "dev": true + "integrity": "sha512-f3qQ9oQy9j2AhBe/H9VC91wLmKBCCU/gDOnKNAYG5hswO7BLKj09Hc5HYNz9cGI++xlpDCIgDaitVs03ATR84Q==" }, "node_modules/json-schema-traverse": { "version": "1.0.0", "resolved": "https://registry.npmjs.org/json-schema-traverse/-/json-schema-traverse-1.0.0.tgz", - "integrity": "sha512-NM8/P9n3XjXhIZn1lLhkFaACTOURQXjWhV4BA/RnOv8xvgqtqpAX9IO4mRQxSx1Rlo4tqzeqb0sOlruaOy3dug==", - "dev": true + "integrity": "sha512-NM8/P9n3XjXhIZn1lLhkFaACTOURQXjWhV4BA/RnOv8xvgqtqpAX9IO4mRQxSx1Rlo4tqzeqb0sOlruaOy3dug==" }, "node_modules/make-error": { "version": "1.3.6", @@ -183,7 +181,6 @@ "version": "2.3.1", "resolved": "https://registry.npmjs.org/punycode/-/punycode-2.3.1.tgz", "integrity": "sha512-vYt7UD1U9Wg6138shLtLOvdAu+8DsC/ilFtEVHcH+wydcSpNE20AfSOduf6MkRFahL5FY7X1oU7nKVZFtfq8Fg==", - "dev": true, "engines": { "node": ">=6" } @@ -192,7 +189,6 @@ "version": "2.0.2", "resolved": "https://registry.npmjs.org/require-from-string/-/require-from-string-2.0.2.tgz", "integrity": "sha512-Xf0nWe6RseziFMu+Ap9biiUbmplq6S9/p+7w7YXP/JBHhrUDDUhwa+vANyubuqfZWTveU//DYVGsDG7RKL/vEw==", - "dev": true, "engines": { "node": ">=0.10.0" } @@ -263,7 +259,6 @@ "version": "4.4.1", "resolved": "https://registry.npmjs.org/uri-js/-/uri-js-4.4.1.tgz", "integrity": "sha512-7rKUyy33Q1yc98pQ1DAmLtwX109F7TIfWlW1Ydo8Wl1ii1SeHieeh0HHfPeL2fMXK6z0s8ecKs9frCuLJvndBg==", - "dev": true, "dependencies": { "punycode": "^2.1.0" }